The name "Sopchoppy" is supposedly a corruption of the Muskogee "lokchapi" (acorn stem), the Indian name for the nearby river. There was a settlement across the river named Greenough that was in place before the CT&G Railroad came through. But as usual with railroads, they built a siding and platted a town on land they owned... then encouraged the folks of Greenough to buy from them and move. So Sopchoppy was first platted in 1894, then the railroad developers began a sales campaign built around exaggerating the quality of the soil and climate...

Sopchoppy is located on the Big Bend Scenic Byway, just north of Ochlockonee River State Park. Bald Point State Park is only a few miles further to the south, Tate's Hell State Forest a few miles to the west. To the north is Apalachicola National Forest, to the east St. Marks National Wildlife Refuge. Sopchoppy is just south of the Bradwell Bay and Mud Swamp-New River Wilderness Areas.

The population of Sopchoppy is up a bit more than 7% since 2000.