Wakulla County is located in the Florida Panhandle on the Gulf of Mexico. Wakulla County contains 700 square miles of land area and 36 square miles of water surface. The county seat is Crawfordville.

In 1539, Hernando de Soto came to Wakulla County and had his men build San Marcos de Apalache, a fort that later became known as St. Marks.

In the heyday of north Florida's cinema boom, parts of Creature from the Black Lagoon and parts of several of Johnny Weissmuller's Tarzan movies were filmed in and around the crystal clear rivers of Wakulla County.

Wakulla County contains part of the Apalachicola National Forest (with the Bradwell Bay Wilderness) and part of St. Marks National Wildlife Refuge. The lighthouse at St. Marks was one of the first lighthouses built on the shores of the Gulf of Mexico.